Biomedical Engineering

Distinguished Seminar Series: Elizabeth Meyerand, Biomedical Engineering, University of Wisconsin-Madison

January 07, 2016
4:10 pm to 5:00 pm

Meyerand

M. Elizabeth Meyerand, Ph.D. Vilas Distinguished Achievement Professor, Departments of Biomedical Engineering and Medical Physics Chair, Department of Biomedical Engineering University of Wisconsin-Madison

“A fMRI Study of Sustained Neuromodulation Induced by Electrical Tongue Stimulation in Balance Disorders”

Neurostimulation has emerged as a promising approach to precisely target and modify activity within neuronal structures. The flexibility of this technique has made it a useful tool for research into normal brain function, and as a potential therapy for many neurological disorders. Electrical stimulation through the tongue offers multiple advantages over other routes of administration including access to the central nervous system without invasive surgeries, the ability to stimulate using low voltages (< 12 V), high receptor density allowing high data throughput, and a very compact stimulation device liberated from accessory equipment and the need for a permanent power source. Recent studies suggest that stimulation through the tongue can produce sustained behavioral and subjective improvements in individuals with chronic balance disorders, even when the stimulation device has been removed. We have demonstrated that physical therapy measures show information-free stimulation through the tongue, termed cranial nerve non-invasive neuromoduation (CN-NINM), can indeed produce sustained improvements in the functional deficits and subjective symptoms in subjects with balance disorders. Subsequently, we applied advanced analysis techniques to functional magnetic resonance imaging (fMRI) data in order to investigate balance-processing dysfunction in these individuals compared to healthy controls. Results suggest that balance-impaired individuals have visual motion-dependent hypersensitivity of the entire balance-processing network, extending previous findings that this hypersensitivity was limited to the visual cortices. We then compared network processing before and after individuals with balance disorders received information-free tongue stimulation. We found that CN-NINM normalizes the network response to visual-motion and likely induces sustained neuromodulation of the trigeminal nuclei of the brainstem – the site at which the incoming stimulation enters the central nervous system. Collectively, the work provides a preliminary understanding of how electrical tongue stimulation modulates the balance-processing network to produce long-term behavioral improvements in individuals with balance disorders.

Location
1005 GBSF

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