“From Optical Spectroscopy to Spectroscopic Imaging”
Epithelial tissue is layered, but most optical probes average signals from a large tissue volume. This method limits the accuracy of optical diagnosis in epithelial cancers and precancers. In response to this challenge, we have published one of the first papers for in-depth sensitive fluorescence spectroscopy using an angled fiber-optic probe design. To overcome the limitation of the fiber-optic probe in optical coupling uncertainty, we have proposed multiple lens based systems to perform depth sensitive optical spectroscopy. Moreover, relevant numerical tools based on the Monte Carlo method were also developed to facilitate the optimization of such systems.
Biography: Dr. Quan Liu received the PhD degree in Biomedical Engineering from the University of Wisconsin, Madison. He is currently an assistant professor in the School of Chemical and Biomedical Engineering at Nanyang Technological University in Singapore. His research interest is focused on optical imaging and spectroscopy for medical diagnostics. Dr. Liu has served as a reviewer for several top journals, such as Optics Letters, Optics Express and Nature Communications, and multiple international funding agencies as well as a subcommittee member and session chair for multiple international conferences such as European Conferences in Biomedical Optics (ECBO) and Photonics West. Dr. Liu is a senior SPIE member and a regular OSA member.