Publications

 

JOURNAL

2014 | 2013 | 2012 | 2011 | 2010 | 2009

2008 | 2007 | 2006 | 2005 | 2004

2014

V.J. Srinivasan and H. Radhakrishnan, “Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation,” Accepted in Neuroimage (2014).

A.C. Chan, V.J. Srinivasan, and E.Y. Lam, “Maximum Likelihood Doppler frequency estimation under decorrelation noise for quantifying flow in Optical Coherence Tomography,” IEEE Trans. Med. Imaging 33(6) : 1313-1323, (2014) (link)

2013

C. Leahy, H. Radhakrishnan, V.J. Srinivasan, “Volumetric imaging and quantification of cytoarchitecture and myeloarchitecture with intrinsic scattering contrast,” Biomed. Opt. Express 4(10): 1978-1990, (2013) (link)

H. Radhakrishnan and V.J. Srinivasan, “Multi-parametric OCT imaging of the inner retinal hemodynamic response to visual stimulation,” J Biomed Opt. 18(8):086010, (2013) (link)

V.J. Srinivasan, E.T. Mandeville, A. Can, F. Blasi, M. Climov, A. Daneshmand, J.H. Lee, E. Yu, H. Radhakrishnan, E.H. Lo, S. Sakadzic, K. Eikermann-Haerter, C. Ayata, “Multiparametric, longitudinal optical coherence tomography reveals acute injury and chronic recovery in experimental ischemic stroke,” PLoS One 8(8):871478, (2013) (link). This study was featured on the OCT News website ‘Feature of The Week‘.

V.J. Srinivasan and H. Radhakrishnan, “Total average blood flow and angiography in the rat retina,” J Biomed Opt. 18(7):076025, (2013) (link)

H. Radhakrishnan and V.J. Srinivasan, “Compartment-resolved imaging of cortical functional hyperemia with OCT angiography,” Biomed. Opt. Express 4(8):1255-1268, (2013) (link). This paper is featured in Spotlight on Optics.

A.C. Chan, E.Y. Lam, and V.J. Srinivasan, “Comparison of Kasai autocorrelation and maximum likelihood estimators for Doppler Optical Coherence Tomography,” IEEE Trans. Med. Imaging 32(6):1033-1042, (2013) (link).

2012

C.J. Goergen, H. Radhakrishnan, S. Sakadzic, E.T. Mandeville, E.H. Lo, D.E. Sosnovik, and V.J. Srinivasan, “Optical coherence tractography using intrinsic contrast,” Opt. Lett. 37(18):3882-3884, (2012) (link).

A. Devor, S. Sakadžic, V.J. Srinivasan, M.A. Yaseen, K. Nizar, P.A. Saisan, P. Tian, A.M. Dale, S.A. Vinogradov, M.A. Franceschini, and D.A. Boas, “Frontiers in optical imaging of cerebral blood flow and metabolism,” J Cereb. Blood Flow Metab. 32(7):1259-1276, 2012 (link).

V.J. Srinivasan, H. Radhakrishnan, E.T. Mandeville, E.H. Lo, J.Y. Jiang, S.E. Barry, and A.E. Cable, “OCT Methods for Capillary Velocimetry,” Biomed. Opt. Exp. 3(3):612-629, 2012 (link).

V.J. Srinivasan, H. Radhakrishnan, J.Y. Jiang, S.E. Barry, and A.E. Cable, “Optical Coherence Microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast,” Opt. Exp. 20(3):2220-2239, 2012 (link).

I. Yuzawa, S. Sakadzic, V.J. Srinivasan, H.K. Shin, K. Eikermann-Haerter, D.A. Boas, and C. Ayata, “Cortical spreading depression impairs oxygen delivery and metabolism in mice,” J. Cereb. Blood Flow Metab. 32(2):376-86, 2012 (link).

2011

E. Baraghis, V. Bolduc, J. Lefebvre, V.J. Srinivasan, C. Boudoux, E. Thorin, and F. Lesage, “Measurement of cerebral microvascular compliance in a model of atherosclerosis with optical coherence tomography,” Biomed. Opt. Exp. 2(11):3079-3093, 2011 (link).

E. Baraghis, A. Devor, Q. Fang, V.J. Srinivasan, W. Wu, F. Lesage, C. Ayata, K. Kasischke, D.A. Boas, and S. Sakadzic, “Two-photon microscopy of cortical NADH fluorescence intensity changes: Correcting contamination from the hemodynamic response,” J Biomed. Opt. 16(10):106003, 2011 (link).

A. Devor, S. Sakadzic, P.A. Saisan, M.A. Yaseen, E. Roussakis, V.J. Srinivasan, S.A. Vinogradov, B.R. Rosen, R.B. Buxton, A.M. Dale, and D.A. Boas, “Overshoot of o2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels,” J. Neurosci. 31(38):13676-81, 2011 (link).

S.A. Carp, N. Roche-Labarbe, M.A. Franceschini, V.J. Srinivasan, S. Sakadžić, and D.A. Boas, “Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels,” Biomed. Opt. Exp. 2(7):2047-2054, 2011 (link).

V.J. Srinivasan, D.N. Atochin, J.Y. Jiang, H. Radhakrishnan, S. Ruvinskaya, W. Wu, S. Barry, A.E. Cable, C. Ayata, P.L. Huang, D.A. Boas, “Optical Coherence Tomography for the Quantitative Study of Cerebrovascular Physiology,” J Cereb Blood Flow Metab. 31(6):1339-1345, 2011 (link).

S. Sakadzic, E. Roussakis, M.A. Yaseen, E.T. Mandeville, V.J. Srinivasan, K. Arai, S. Ruvinskaya, W. Wu, A. Devor, E.H. Lo, S.A. Vinogradov, and D.A. Boas, “Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence,” J Vis. Exp. 51:e1694, 2011 (link).

M.A. Yaseen, V.J. Srinivasan, S. Sakadžić, W. Wu, S. Ruvinskaya, S.A. Vinogradov, and D.A. Boas, “Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation,” J Cereb Blood Flow Metab. 31(4):1051-1063, 2011 (link).

C.H. Judson, L.N. Vuong, I. Gorczynska, V.J. Srinivasan, J.G. Fujimoto, and J.S. Duker, “Intact Retinal Tissue and Retinal Pigment Epithelium Identified within a Coloboma Via High-Speed, Ultrahigh Resolution Optical Coherence Tomography,” Retin. Cases Brief Rep. 5(1), 46-48, Winter 2011 (link).

2010

S. Sakadžić, E. Roussakis, M.A. Yaseen, E.T. Mandeville, V.J. Srinivasan, K. Arai, S. Ruvinskaya, A. Devor, E.H. Lo, S.A. Vinogradov, and D.A. Boas, “Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue, ” Nat. Meth. 7(9): 755-759, 2010 (link).

V.J. Srinivasan, S. Sakadžić, I. Gorczynska, S. Ruvinskaya, W. Wu, J.G. Fujimoto, and D.A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Exp. 18(3):2477-2494, 2010 (link).

A.C. Sull, L.N. Vuong, L.L. Price, V.J. Srinivasan, I. Gorczynska, J.G. Fujimoto, J.S. Schuman, and J.S. Duker, “Comparison of spectral Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2):235-245, 2010 (link).

V.J. Srinivasan, J.Y. Jiang, M.A. Yaseen, H. Radhakrishnan, W. Wu, S. Barry, A.E. Cable, and D.A. Boas, “Rapid volumetric angiography of cortical microvasculature with optical coherence tomography,” Opt. Lett. 35(1):43-45, 2010 (link).

2009

M.A. Yaseen, V.J. Srinivasan, S. Sakadžić, W. Wu, S. Ruvinskaya, S.A. Vinogradov, and D.A. Boas, “Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy,” Opt. Exp. 17(25):22341-22350, 2009 (link).

V.J. Srinivasan, S. Sakadžić, I. Gorczynska, S. Ruvinskaya, W. Wu, J.G. Fujimoto, and D. Boas, “Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography,” Opt. Lett. 34(20):3086-3088, 2009 (link).

A.J. Witkin, L.N. Vuong, V.J. Srinivasan, I. Gorczynska, E. Reichel, C.R. Baumal, A.H. Rogers, J.S. Schuman, J.G. Fujimoto, and J.S. Duker, “High-speed ultrahigh resolution optical coherence tomography before and after ranibizumab for age-related macular degeneration,” Ophthalmology 116(5):956-963, 2009 (link).

I. Gorczynska, V.J. Srinivasan, L.N. Vuong, R.W.S. Chen, J.J. Liu, E. Reichel, M. Wojtkowski, J.S. Schuman, J.S. Duker, and J.G. Fujimoto, “Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration,” Br. J Ophthalmol. 93(5):603-609, 2009 (link).

V.J. Srinivasan, Y. Chen, J.S. Duker, and J.G. Fujimoto, “In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT,” Opt. Exp. 17(5):3861-3877, 2009 (link).

Y. Chen, L.N. Vuong, J. Liu, J. Ho, V.J. Srinivasan, I. Gorczynska, A.J. Witkin, J.S. Duker, J. Schuman, and J.G. Fujimoto, “Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration,” Opt. Exp. 17(5):4046-4060, 2009 (link).

2008

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, “Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head,” Invest. Ophthalmol. Vis. Sci. 49(11):5103-5110, 2008 (link).

B.R. Biedermann, W. Wieser, C.M. Eigenwillig, G. Palte, D.C. Adler, V.J. Srinivasan, J.G. Fujimoto, and R. Huber, “Real time en face Fourier-domain optical coherence tomography with direct hardware frequency demodulation,” Opt. Lett. 33(21):2556-2558, 2008 (link).

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, “Ultrahigh speed spectral/Fourier domain optical coherence tomography ophthalmic imaging at 70,000-312,500 axial scans per second,” Opt. Exp. 16(19):15149-15169, 2008 (link).

M.L. Gabriele, H. Ishikawa, G. Wollstein, R.A. Bilonick, K.A. Townsend, L. Kagemann, M. Wojtkowski, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, and J.S. Schuman, “Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability,” Invest. Ophthalmol. Vis. Sci. 49(6):2315-2321, 2008 (link).

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M.L. Gabrielle, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, and J.S. Schuman, “Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography,” Ophthalmology 115(5):782-789, 2008 (link).

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, “Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(4):1571-1579, 2008 (link).

R.W. Chen, I. Gorczynska, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, and E. Reichel, “High-speed ultrahigh-resolution optical coherence tomography findings in chronic solar retinopathy,” Retin. Cases Brief Rep. 2(2):103-105, Spring 2008 (link).

2007

A.J. Witkin, M. Wojtkowski, E. Reichel, V.J. Srinivasan, J.G. Fujimoto, J.S. Schuman, and J.S. Duker, “Photoreceptor disruption secondary to posterior vitreous detachment as visualized using high-speed ultrahigh-resolution optical coherence tomography,” Arch. Ophthalmol. 125(11):1579-1580, 2007 (link).

M.K. Yoon, R.W. Chen, T.R. Hedges, III, V.J. Srinivasan, I. Gorczynska, J.G. Fujimoto, M. Wojtkowski, J.S. Schuman, and J.S. Duker, “High-speed, ultrahigh resolution optical coherence tomography of the retina in Hunter syndrome,” Ophthalmic Surg. Lasers Imaging 38(5):423-428, 2007 (link).

V. Christopoulos, L. Kagemann, G. Wollstein, H. Ishikawa, M.L. Gabriele, M. Wojtkowski, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, D.K. Dhaliwal, and J.S. Schuman, “In vivo corneal high-speed, ultra-high-resolution optical coherence tomography,” Arch. Ophthalmol. 125(8):1027-1035, 2007 (link).

L. Kagemann, G. Wollstein, M. Wojtkowski, H. Ishikawa, K.A. Townsend, M.L. Gabriele, V.J. Srinivasan, J.G. Fujimoto, and J.S. Schuman, “Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography,” J Biomed. Opt. 12(4), 041212, 2007 (link).

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmoska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, “Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies,” J Biomed. Opt. 12(4):041207, 2007 (link).

R. Huber, D.C. Adler, V.J. Srinivasan, I. Gorczynska, and J.G. Fujimoto, “Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second,” Opt. Lett. 32(14):2049-2051, 2007 (link).

M.L. Gabriele, H. Ishikawa, G. Wollstein, R.A. Bilonick, L. Kagemann, M. Wojtkowski, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, and J.S. Schuman, “Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning,” Invest. Ophthalmol. Vis. Sci. 48(7):3154-3160, 2007 (link).

J.A. Rodriguez-Padilla, T.R. Hedges, III, B. Monson, V.J. Srinivasan, M. Wojtkowski, E. Reichel, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, “High-speed, ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy,” Arch. Ophthalmol. 125(6):775-780, 2007 (link).

M.Y. Kahook, R.J. Noecker, H. Ishikawa, G. Wollstein, L. Kagemann, M. Wojtkowski, J.S. Duker, V.J. Srinivasan, J.G. Fujimoto, and J.S. Schuman, “Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure,” Am. J Ophthalmol. 143(4):697-699, 2007 (link).

V.J. Srinivasan, R. Huber, I. Gorczynska, J.G. Fujimoto, J.Y. Jiang, P. Riesen, and A.E. Cable, “High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850nm,” Opt. Lett. 32(4):361-363, 2007 (link).

B.B. Gao, A. Clermont, S. Rook, S.J. Fonda, V.J. Srinivasan, M. Wojtkowski, J.G. Fujimoto, R.L. Avery, P.G. Arrigg, S.-E. Bursell, L.P. Aiello, and E.P Feener, “Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrean activation,” Nat. Med. 13(2):181-188, 2007 (link).

B.K. Monson, P.B. Greenberg, E. Greenberg, J.G. Fujimoto, V.J. Srinivasan, and J.S. Duker, “High-speed, ultra-high-resolution optical coherence tomography of acute macular neuroretinopathy,” Br. J Ophthalmol. 91(1):119-120, 2007 (link).

2006

V.J. Srinivasan, T.H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S.-E. Bursell, Q.H. Song, J. Lem, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh resolution OCT,” Invest. Ophthalmol. Vis. Sci. 47(12):5522-5528, 2006 (link).

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, “High-definition and three-dimensional imaging of macular pathologies with high-speed, ultrahigh resolution optical coherence tomography,” Ophthalmology 113(11):2054.e1-2054.e14, 2006 (link).

L. Kagemann, G. Wollstein, H. Ishikawa, M.L. Gabrielle, V.J. Srinivasan, M. Wojtkowski, J.S. Duker, J.G. Fujimoto, and J.S. Schuman, “Persistence of Cloquet’s canal in normal healthy eyes,” Am. J. Ophthalmol. 142(5):862-864, 2006 (link).

V.J. Srinivasan, M. Wojtkowski, J.G. Fujimoto, and J.S. Duker, “In vivo measurement of retinal physiology with high-speed ultrahigh resolution optical coherence tomography,” Opt. Lett. 31(15):2308-2310, 2006 (link).

2005

M. Wojtkowski, V.J. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, “Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography,” Ophthalmology 112(10):1734-1746, 2005 (link).

2004

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Exp. 12(11):2404-2422, 2004 (link).

POPULAR

1. Lynda Charters, “Advanced OCT opens way for 3-D retinal images,” Ophthalmology Times, 8/15/2005.

2. Elizabeth A. Thompson, “MIT team takes high-res, 3-D images of eye,” MIT news, http://web.mit.edu/newsoffice/2007/eye-imaging.html.

3. Royce W.S. Chen, BA; Jay S. Duker, MD; Vivek Srinivasan, MS; and James G. Fujimoto, “Speed and Resolution Improve in Newest OCT,” Review of Ophthalmology, http://www.optovue.com/pdf/SpeedAndResolutionImproveInOCT.pdf.

4. “Cerebral Blood Flow,” Research Highlights, Nature Photonics, 4/2010. (link)

5. “Doppler optical coherence tomography for imaging of brain hemodynamics,” SPIE Newsroom, Biomedical Optics & Medical Imaging, http://spie.org/x41191.xml?ArticleID=x41191, 7/2010.

6. “Spectral Domain OCT Employed to Study Cortical Microvasculature,” Thorlabs Application Article, http://www.thorlabs.us/newgrouppage9.cfm?objectgroup_id=5740.

7. “OCT Branches Out,” Biophotonics, http://www.photonics.com/Article.aspx?AID=46016, 2/2011.

8. “Absolute blood flow measured by optical methods,” SPIE Newsroom, Biomedical Optics & Medical Imaging, http://spie.org/x83255.xml?ArticleID=x83255, 11/2011.

9. “Novel Techniques for Measuring Capillary Blood Flow Using OCT,” Thorlabs Application Article, http://www.thorlabs.us/newgrouppage9.cfm?objectgroup_id=6484.

10. Featured Research: The Optical Society . “Precision-guided epidurals, better blood monitors for better care,” Science Daily 27th May 2014. www.sciencedaily.com/releases/2014/05/140527133348.htm

BOOK CHAPTERS

1. V.J. Srinivasan, A.C. Chan, and E.Y. Lam, “Doppler OCT and OCT Angiography for In Vivo Imaging of Vascular Physiology,” Optical Coherence Tomography, ISBN 978-953-307-804-5, InTech. (link)

2. H. Radhakrishnan, M.A. Franceschini, and V.J. Srinivasan, “Neurovascular coupling investigated by simultaneous Optical Coherence Tomography and electrophysiology,” Chapter 2 Neurovascular Coupling Methods, Neuromethods vol 88, Springer. (link).

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