Rodent paw imaging

Recent News

Felipe Godinez wins the Valentin T. Jordanov Radiation Instrumentation Award for building the first dedicated PET scanner for mouse paws (pawPET)

Brief description

PET image of the arthritic mouse paw; conventional method (left) and the UC Davis method (right)

Our group is validating imaging modalities such as small-animal PET/CTand MRI for the quantification of inflammatory arthritic activity during disease progression in a  murine model. The goal of this work is to validate imaging biomarkers that may be used in pre-clinical studies of the inflammatory arthritic disease process and for monitoring of response to treatment in a non-invasive, in vivo manner. Our research group has also built the world’s first dedicated PET scanner (called ‘pawPET’) that allows for better quantification of disease activities in the joints of the mouse paw. We are also developing image processing methods that allow for the improved derivation of imaging biomarkers of inflammatory arthritis.

Research team

UC Davis: Abhijit J. Chaudhari, Ph.D., Ramsey D. Badawi, Ph.D., Julie L. Sutcliffe, Ph.D. Simon R. Cherry, Ph.D., Jinyi Qi, Ph.D., Jian Zhou, Ph.D., Felipe Godinez, Ph.D.

VA Medical Center/UC Davis: Siba P. Raychaudhuri, M.D., Smriti Raychaudhuri, M.D., Anupam Mitra, M.D.

Research Support

UC Davis Clinical and Translational Sciences Center, UC Davis Center for Molecular and Genomic Imaging

Relevant publications

S. K. Raychaudhuri, A. Mitra, K. Gong, J. Zhou, J. Qi, S. P. Raychaudhuri and A. J. Chaudhari, In vivo quantification of joint inflammation in a murine arthritis model by anato-molecular imaging, American College of Rheumatology Annual Meeting (2012)
F. Godinez, A. J. Chaudhari, J. Fung, Y. Yang, R. Farrell, S. K. Raychaudhuri, S. P. Raychaudhuri and Ramsey D. Badawi, pawPET: a high sensitivity, high resolution PET scanner for rodent paws, IEEE Nucl. Sci. Symp. Conf. (2012)

Interested in knowing more

Please contact Dr Chaudhari at ajchaudhari AT ucdavis DOT edu

 

Comments are closed.