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Our group is validating imaging modalities such as small-animal PET/CTand MRI for the quantification of inflammatory arthritic activity during disease progression in a murine model. The goal of this work is to validate imaging biomarkers that may be used in pre-clinical studies of the inflammatory arthritic disease process and for monitoring of response to treatment in a non-invasive, in vivo manner. Our research group has also built the world’s first dedicated PET scanner (called ‘pawPET’) that allows for better quantification of disease activities in the joints of the mouse paw. We are also developing image processing methods that allow for the improved derivation of imaging biomarkers of inflammatory arthritis.
UC Davis: Abhijit J. Chaudhari, Ph.D., Ramsey D. Badawi, Ph.D., Julie L. Sutcliffe, Ph.D. Simon R. Cherry, Ph.D., Jinyi Qi, Ph.D., Jian Zhou, Ph.D., Felipe Godinez, Ph.D.
VA Medical Center/UC Davis: Siba P. Raychaudhuri, M.D., Smriti Raychaudhuri, M.D., Anupam Mitra, M.D.
UC Davis Clinical and Translational Sciences Center, UC Davis Center for Molecular and Genomic Imaging
S. K. Raychaudhuri, A. Mitra, K. Gong, J. Zhou, J. Qi, S. P. Raychaudhuri and A. J. Chaudhari, In vivo quantification of joint inflammation in a murine arthritis model by anato-molecular imaging, American College of Rheumatology Annual Meeting (2012)
Interested in knowing more
Please contact Dr Chaudhari at ajchaudhari AT ucdavis DOT edu