Biomedical Engineering

Karen Moxon

Professor

GBSF 2519

530-752-8156

moxon@ucdavis.edu

 

 

Education

  • PhD, University of Colorado, Systems Engineering, 1994 
  • MS, University of Colorado, Systems Engineering, 1991
  • BS, University of Michigan, Chemical Engineering, 1984

Research Interests

Computational modeling, neural modeling, neurorobotics, neuromimetics, neurocontrol, multiple,single neuron recording.

Bio

Dr. Moxon has conducted ground breaking research in neuroengineering, developing computational approaches to study the encoding of sensory and motor information. An important focus of her work is the impact of neural injury on the representation of information in the brain. Early in her career, she contributed to the first demonstration of a closed-loop, real-time brain-machine interface system in a rat model that was quickly translated to non-human primates and, more recently, to humans with neurological disorders. This work has spurred an entirely new discipline within neuroengineering that has had a global impact. Dr. Moxon maintains an active research program, combining signal processing and the development of neural interface devices with computational approaches to study how changes in neural encoding contribute to recovery of function after spinal cord injury.

Patents

  • “Optoelectronic Remotely Powered Silicon-based Hybrid Neural Electrode”, Registration No. 36,317, Filing Date July 21, 2008.
  • “Chronic, in-vivo neurotransmitter sensor”, Serial No. US11/879,616, Filing Date July 18, 2007.
  • “Wireless controlled neuromodulation system” Serial No. US11/753,256 Filing Date May 24, 2007.
  • “Method to quantitatively measure effect of psychotropic drugs on sensory discrimination”, Serial No. 60/760,211, Filing Date January 19, 2006, pending.
  • “Ceramic based multi-site electrode arrays and methods for their production”, serial No. 09/000,601, Filing Date, October 19, 2001, Awarded September, 2004.

Selected Publications

  1. Karunakaran S, Grasse DW, Moxon KA. Role of CA3 theta-modulated interneurons during the transition to spontaneous seizures. Experimental Neurology 283(Pt A):341-52, 2016 PubMed PMID: 27353968
  2. Ganzer PD, Manohar A, Shumsky JS, Moxon KA. Therapy induces widespread reorganization of motor cortex after complete spinal transection that supports motor recovery. Experimental Neurology 279:1-12, 2016 PubMed PMID: 26826448.
  3. Moxon, KA, Foffani G Brain-Machine Interfaces Beyond Neuroprosthetics, Neuron, 86(1):55-67, 2015.
  4. Knudsen EB, Powers ME, Moxon, KA Dissociating movement from movement timing in the rat primary motor cortex, J Neuroscience, 34(47):15576-86, 2014.
  5. Moxon KA, Oliviero A, Aguilar J, Foffani G. Cortical reorganization after spinal cord injury: Always for good? Neuroscience, 283:78-94, 2014.
  6. Scaglione A, Foffani G Moxon KA Spike count, spike timing and temporal information in the cortex of awake, freely moving rats, Journal of Neural Engineering, 11(4):046022, 2014.
  7. Misra, A, Burke J, Ramayya A, Jacobs J, Sperling M, Moxon K, Kahana M, Evans J, Sharan A Methods for implantation of micro-wire bundles and optimization of single/multiunit recordings from human mesial temporal lobe, Journal of Neural Engineering, 11(2):026013, 2014.
  8. Graziano A, Foffani G, Knudsen EB, Shumsky EB, Moxon KA Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization, PLoS One, 8(1): e54350, 2013.
  9. Scaglione S, Moxon KA, Aguilar J, Foffani G Trial-to-trial variability in the responses of neurons carries information about stimulus location in the rat whisker thalamus, Proceedings of the National Academy of Science, 108(36):14956-61. 2011.
  10. Leiser S., Moxon K.A., Response properties of rat trigeminal ganglion neurons during natural whisking behaviors, Neuron, 53(1):117-33, 2007.
border