Passerini Lab

Our research lies at the interface of vascular inflammation and endothelial mechanobiology, and addresses the mechanisms of endothelial vulnerability leading to atherosclerosis. We apply a multidisciplinary systems approach, and develop novel technologies and protocols to test how arterial hemodynamics locally regulates inflammation induced by systemic risk factors for vascular disease to affect lesion formation. The outcomes of this work will be the elucidation of a vulnerable endothelial phenotype and a better understanding of mechanisms to guide the development of novel strategies to prevent, diagnose and treat cardiovascular disease.

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