Biomedical Engineering

Leonor Saiz's Latest Publication is a Featured Article in Nucleic Acids Research Journal

The Nucleic Acids Research journal has highlighted Leonor Saiz’s latest work as a featured article ( As stated on the journal’s website: “featured articles represent the top 5% of papers in terms of originality, significance and scientific excellence”. The journal said of Prof. Saiz’s paper:

“This manuscript describes a new layer of control of gene expression that results from a set of elements that are common to a wide variety of essential regulators, including p53, NF-kB, STATs, Oct, and RXR. The key concept that emerges from the authors’ results is that modulation of the oligomerization state of this type of transcription factors provides a precise mechanism for the control of transcription by different types of signals, such as ligand binding, phosphorylation, and acetylation, with flexible properties that can be adjusted both at a genome-wide scale and at the individual promoter level.”

The article has recently appeared online ahead of print (as “advanced access”) and it has the following temporary reference: J.M.G. Vilar and L. Saiz, Control of gene expression by modulated self-assembly, Nucleic Acids Research, doi:1093/nar/gkr272 (2011). The article is available at: