Graduate Courses in Biomedical Engineering

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BIM 201 Scientific Communication for Biomedical Engineers Units: 1
Course is designed to improve the written and oral communication skills of first-year graduate students through writing fellowship proposals, analyzing data, and critically reviewing research papers
BIM 202 Cell and Molecular Biology for Engineers Units: 4
Preparation for research and critical review in the field of cell and molecular biology for biomedical or applied science engineers. Emphasis on biophysical and engineering concepts intrinsic to specific topics including protein traffic, the cytoskeleton, cell motility, cell division, and cell adhesion. Modern topics in mechano-biology of cancer cells and stem cells.
BIM 204 Physiology for Bioengineers Units: 5
Basic human physiology of the nervous, muscular, cardiovascular, respiratory, endocrine, lymphatic, renal and gastrointestinal systems and their interactions. Emphasis is placed on the physical and engineering principles governing these systems, including control and transport processes, fluid dynamics, and electrochemistry.
BIM 209 Scientific Integrity for Biomedical Engineers Units: 2
Scientific integrity and ethics for biomedical engineers, with emphasis and discussion on mentoring, authorship and peer review, use of humans and animals in biomedical research, conflict of interest, intellectual property, genetic technology and scientific record keeping.
BIM 210 Introduction to Biomaterials Units: 4
Mechanical and atomic properties of metallic, ceramic, and polymeric of implant materials; corrosion, degradation, and failure of implants; inflammation, wound and fracture healing, blood coagulation; properties of bones, joints, and blood vessels; biocompatibility of orthopedic and cardiovascular materials. Offered in alternate years
BIM 211 Design of Polymeric Biomaterials and Biological Interfaces Units: 4
Design, selection and application of polymeric biomaterials. Integration of the principles of polymer science, surface science, materials science and biology.
BIM 212 Biomedical Heat and Mass Transport Processes Units: 4
Application of principles of heat and mass transfer to biomedical systems; related to heat exchange between the biomedical system and its environment, mass transfer across cell membranes and the design and analysis of artificial human organs. Offered in alternate years.
BIM 213 Principles and Applications of Biological Sensors Units: 4
Biological sensors based on principles of electrochemical, optical and affinity detection. Methods for integration of sensing elements (e.g. enzymes) into biosensors and miniaturization of biosensors.
BIM 214 Continuum Biomechanics Units: 4
Continuum mechanics relevant to bioengineering. Concepts in tensor calculus, kinematics, stress and strain, and constitutive theories of continua. Selected topics in bone, articular cartilage, blood/circulation, and cell biomechanics will illustrate the derivation of appropriate continuum mechanics theories.
BIM 216 Advanced topics in Cellular Engineering Units: 4
Advanced research strategies and technologies used in the study of immune function and inflammation. Static and dynamic measurements of stress, strain, and molecular scale forces in blood and vascular cells, as well as genetic approaches to the study of disease.
BIM 217 Mechanobiology in Health and Disease Units: 4
Principles by which biomechanical forces affect cell and tissue function to impact human health and disease. Emphasis on cardiovascular system: structure and function, biofluid mechanics and mechanotransduction, disease mechanisms and research methods. Cartilage, bone and other systems; current topics discussed.
BIM 218 Microsciences Units: 4
Introduction to the theory of physical and chemical principles at the microscale. Scale effects, surface tension, microfluidic mechanics, micromechanical properties, intermolecular interactions and micro tribology.
BIM 221 Drug Delivery Systems Units: 4
Fundamental engineering and biotechnology principles critical for the formulation and delivery of therapeutic agents, including peptide/protein drugs and small molecules.
BIM 222 Cytoskeletal Mechanics Units: 4
Current topics in cytoskeletal mechanics including physical properties of the cytoskeleton and motor proteins, molecular force sensor and generator, cytoskeletal regulation of cell motility and adhesion. Offered in alternate years.
BIM 223 Multibody Dynamics Units: 4
Coupled rigid-body kinematics/dynamics; reference frames; vector differentiation; configuration and motion constraints; holonomicity; generalized speeds; partial velocities; mass; inertia tensor/theorems; angular momentum; generalized forces; comparing Newton/Euler, Lagrange’s, Kane’s methods; computer-aided equation derivation; orientation; Euler; Rodrigues parameters.
BIM 225 Spatial Kinematics and Robotics Units: 4
Spatial kinematics, screw theory, spatial mechanisms analysis and synthesis, robot kinematics and dynamics, robot workspace, path planning, robot programming, real-time architecture and software implementation. Offered in alternate years
BIM 228 Skeletal Muscle Mechanics: Form, Function, Adaptability Units: 4
Form, Function, Adaptability Basic structure and function of skeletal muscle is examined at the microscopic and macroscopic level. Muscle adaptation in response to aging, disease, injury, exercise, and disuse. Analytic models of muscle function are discussed.
BIM 232 Skeletal Tissue Mechanics Units: 3
An overview of the mechanical properties of the various tissues in the musculoskeletal system, the relationship of these properties to anatomic and histologic structure, and the changes in these properties caused by aging and disuse. The tissues to be covered include bone, cartilage and synovial fluid, ligament and tendon.
BIM 233 Soft Tissue Mechanics Units: 4
Presentation of structure and function of musculoskeletal soft tissues: cartilage, tendon, ligament, meniscus, and intervertebral disc. Instruction in engineering principals governing the mechanical behavior of these tissues: viscoelasticity, quasilinear viscoelasticity, and biphasic theory
BIM 239 Advanced Finite Elements and Optimization Units: 4
Introduction to advanced finite elements and design optimization methods, with application to modeling of complex mechanical, aerospace and biomedical systems. Application of states of the art in finite elements in optimum design of components under realistic loading conditions and constraints. Offered in alternate years.
BIM 240 Computational Methods in Nonlinear Mechanics Units: 4
Deformation of the solids and the motion of fluids are treated with state-of-the-art computational methods. Numerical treatment of nonlinear dynamics; classification of coupled problems; applications of finite element methods to mechanical, aeronautical, and biological systems. Offered in alternate years.
BIM 241 Introduction to Magnetic Resonance Imaging Units: 3
Introduction to equipment, methods, medical applications of MRI. Lectures review basic, advanced pulse sequences, image reconstruction, display and technology and how these are applied clinically.
BIM242 Introduction to Biomedical Imaging Units: 4
Basic physics and engineering principles of image science. Emphasis on ionizing and nonionizing radiation production and interactions with the body and detectors. Major imaging systems: radiography, computed tomogra-phy, magnetic resonance, ultrasound, and optical microscopy.
BIM 243 Radiation Detectors for Biomedical Applications Units: 4
Radiation detectors and sensors used for biomedical applications. Emphasis on radiation interactions, detection, measurement and use of radiation sensors for imaging. Operating principles of gas, semiconductor, and scintillation detectors
BIM 251 Medical Image Analysis Units: 4
Techniques for assessing the performance of medical imaging systems. Principles of digital image formation and processing. Measurements that summarize diagnostic image quality and the performance of human observers viewing those images. Definition of ideal observer and other mathematical observers that may be used to predict performance from system design features.
BIM 252 Computational Methods in Biomedical Imaging Units: 4
Analytic tomographic reconstruction from projections in 2D and 3D; model-based image reconstruction methods; maximum likelihood and Bayesian methods; applications to CT, PET, and SPECT.
BIM 254 Statistical Methods in Genomics Units: 4
Statistical approaches to problems in computational molecular biology and genomics; formulation of questions via probabilistic modeling, statistical inference methods for parameter estimation, and interpretation of results to address biological questions; application to high-impact problems in functional genomics and molecular biology.
BIM 255 Nanoscale Imaging for Molecular Medicine Units: 3
Current and emerging technologies to visualize biological structures and processes at size scales = 100 nanometers – and their application towards the advancement of molecular medicine. Technologies include superresolution optical microscopy, electron microscopy and tomography. Emphasis on quantitative imaging
BIM 257 Fundamentals of Tissue Optics and Biomedical Applications Units: 5
Fundamentals of optical properties of tissue. Range of optical technologies and their applications to tissue characterization and diagnostics.
BIM 258 Advanced Biophotonics and Bioimaging Units: 4
Quantitative basis for biophotonics and bioimaging, with an emphasis on the physical and mathematical description of optics, light propagation, and light-tissue interactions. Advantages and limitations of various optical imaging and sensing technologies. Illustrative applications in diagnostics, basic research, and therapy.
BIM 262 Cell and Molecular Biophysics for Bioengineers Units: 4
Introduction to fundamental mechanisms governing the structure, function, and assembly of bio-macromolecules. Emphasis is on a quantitative understanding of the nano-to-microscale interactions between and within individual molecules, as well as of their assemblies, in particular membranes.
BIM 264 Synthetic and Systems Engineering of Cells Units: 4
Introduction to the design, engineering, and control of biological systems for biotechnological applications and biological studies.  Offered in alternate years.
BIM 270 Biochemical Systems Theory Units: 4
Systems biology at the biochemical level. Mathematical and computational methods emphasizing nonlinear representation, dynamics, robustness, and optimization. Case studies of signal-transduction cascades, metabolic networks and regulatory mechanisms. Focus on formulating and answering fundamental questions concerning network function, design, and evolution.
BIM 271 Gene Circuit Theory Units: 4
Analysis, design, and construction of gene circuits. Modeling strategies, elements of design, and methods for studying variations in design. Case studies involving prokaryotic gene circuits to illustrate natural selection, discovery of design principles, and construction of circuits for engineering objectives.
BIM 272 Tissue Engineering Units: 3
Based on morphogenetic signals, responding stem cells and extracellular matrix scaffolding. Design and development of tissues for functional restoration of various organs damaged/lost due to cancer, disease and trauma. Fundamentals of morphogenetic signals, responding stem cells and extracellular matrix scaffolding.
BIM 273 Integrative Tissue Engineering and Technologies Units: 4
Engineering principles to direct cell and tissue behavior and formation. Contents include controlled delivery of macromolecules, transport within and around biomaterials, examination of mechanical forces of engineered constructs, and current experimental techniques used in the field.
BIM 281 Acquisition and Analysis of Biomedical Signals Units: 4
Basic concepts of digital signal recording and analysis; sampling; empirical modeling; Fourier analysis, random, and spectral analysis applied to biomedical signals.
BIM 284 Mathematical Methods for Biomedical Engineers Units: 4
Theoretical and numerical analyses of linear and nonlinear systems, ordinary and partial differential equations that describe biological systems and instruments that measure them. Students will be introduced to
numerical solution techniques.
BIM 286 Nuclear Imaging in Medicine and Biology Units: 4
Radioactive decay, interaction of radiation with matter, radionuclide production, radiation detection, digital autoradiography, gamma camera imaging, single photon emission computed tomography, positron emission tomography and applications of these techniques in biology and medicine.
BIM 287 Concepts in Molecular Imaging Units: 4
Current techniques and tools for molecular imaging. Emphasis on learning to apply principles from the physical sciences to imaging problems in medicine and biology.
BIM 288 Living Matter: Physical Biology of the Cell Units: 3
Introduction to the origin, maintenance, and regulation of the dynamic architecture of the cell, including cellular modes of organization, dynamics and energy dissipation, molecular transport, motility, regulation, and adaptability. Same course as EMS 288 and BPH 288.
BIM 289 A Selected topics in Cell and Molecular Systems Engineering Units: 1-5
BIM 289 B Selected topics in Biomedical Imaging Units: 1-5
BIM 289 C Selected topics in Computational Bioengineering Units: 1-5
BIM 289 D Selected topics in Cell & Tissue Mechanics Units: 1-5
BIM 289 E Selected topics in Analysis of Human Movement Units: 1-5
BIM 290 Graduate Seminar in Biomedical Engineering Units: 1
BIM 290 C Graduate Research Conference Units: 1
BIM 299 Graduate Research Units: 1 – 12
BIM 396 Teaching Assistant Training Practicum Units: 1 – 4



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