Biomedical Engineering

Vivek J. Srinivasan

 

Assistant Professor

(530)-752-9277

Office: 2521 GBSF

vjsriniv@ucdavis.edu

Srinivasan Biophotonics Lab

Personal Education

2003: B.S. in Electrical Engineering, Stanford University

2003: M.S. in Electrical Engineering, Stanford University

2008: Ph.D. in Electrical Engineering and Computer Science (Bioelectrical Engineering), Massachusetts Institute of Technology

Academic Positions

2010-2012: Instructor, Massachusetts General Hospital (Radiology), Harvard Medical School, Charlestown, MA

2012-: Assistant Professor, Biomedical Engineering, UC Davis

Major Research Interests

biophotonics technologies for basic and translational research and clinical diagnostics , neuroimaging, neurovascular coupling, cerebral blood flow and metabolism, in vivo functional optical imaging, light-tissue interactions.

Research Interests

Our laboratory develops optical imaging techniques and diagnostics for investigation of living systems, with applications spanning from basic to clinical research. In particular, we are interested in neuronal control of hemodynamics and metabolism in the central nervous system in health and disease, including the retina and brain. Our highly interdisciplinary approach combines cutting edge optical imaging technologies with collaborations ranging from neuroscience to neurology and ophthalmology to test fundamental hypotheses and explore their diagnostic implications.

 Publications

1. C.J. Goergen, H. Radhakrishnan, S. Sakadzic, E.T. Mandeville, E.H. Lo, D.E. Sosnovik, V.J. Srinivasan, “Optical coherence tractography using intrinsic contrast,” accepted to Optics Letters. 2. A. Devor, S. Sakadžic, V.J. Srinivasan, M.A. Yaseen, K. Nizar, P.A. Saisan, P. Tian, A.M. Dale, S.A. Vinogradov, M.A. Franceschini, D.A. Boas, “Frontiers in optical imaging of cerebral blood flow and metabolism,” J Cereb Blood Flow Metab. Jan 18 (2012). 3. V.J. Srinivasan, H. Radhakrishnan, E.T. Mandeville, E.H. Lo, J.Y. Jiang, S.E. Barry, A.E. Cable, “OCT Methods for Capillary Velocimetry,” Biomed. Opt. Express 3, 612-629 (2012). 4. V.J. Srinivasan, H. Radhakrishnan, J.Y. Jiang, S.E. Barry, A.E. Cable, “Optical Coherence Microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast,” Opt. Express 20, 2220-2239 (2012). 5. I. Yuzawa, S. Sakadzic, V.J. Srinivasan, H.K. Shin, K. Eikermann-Haerter, D.A. Boas, C. Ayata, J. Cereb. Blood Flow Metab. “Cortical spreading depression impairs oxygen delivery and metabolism in mice,” 2012 Feb;32(2):376-86. 6. E. Baraghis, A. Devor, Q. Fang, V.J. Srinivasan, W. Wu, F. Lesage, C. Ayata, K. Kasischke, D.A. Boas, S. Sakadzic, J Biomed Opt. “Two-photon microscopy of cortical NADH fluorescence intensity changes: Correcting contamination from the hemodynamic response,” 2011; 16(10). 7. E. Baraghis, V. Bolduc, J. Lefebvre, V.J. Srinivasan, C. Boudoux, E. Thorin, and F. Lesage, “Measurement of cerebral microvascular compliance in a model of atherosclerosis with optical coherence tomography,” Biomed. Opt. Express 2, 3079-3093 (2011). 8. A. Devor, S. Sakadzic, P.A. Saisan, M.A. Yaseen, E. Roussakis, V.J. Srinivasan, S.A. Vinogradov, B.R. Rosen, R.B. Buxton, A.M. Dale, and D.A. Boas, “Overshoot of o2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels,” J. Neurosci., 31(38) 13676-81 (2011). 9. S. Sakadzic, E. Roussakis, M.A. Yaseen, E.T. Mandeville, V.J. Srinivasan, K. Arai, S. Ruvinskaya, W. Wu, A. Devor, E.H. Lo, S.A. Vinogradov, and D.A. Boas, “Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence,” J Vis Exp (2011). 10. S.A. Carp, N. Roche-Labarbe, M.A. Franceschini, V.J. Srinivasan, S. Sakadžić, and D.A. Boas, “Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels,” Biomedical Opt. Express 2, 2047-2054, June 2011. 11. V.J. Srinivasan, D.N. Atochin, J.Y. Jiang, H. Radhakrishnan, S. Ruvinskaya, W. Wu, S. Barry, A.E. Cable, C. Ayata, P.L. Huang, D.A. Boas, “Optical Coherence Tomography for the Quantitative Study of Cerebrovascular Physiology,” Journal of Cerebral Blood Flow and Metabolism 31, 1339-1345, published online 2 March 2011. 12. M.A. Yaseen, V.J. Srinivasan, S. Sakadžić, W. Wu, S. Ruvinskaya, S.A. Vinogradov, and D.A. Boas, “Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation,” Journal of Cerebral Blood Flow and Metabolism 31, 1051-1063, April 2011. 13. C.H. Judson, L.N. Vuong, I. Gorczynska, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, "Intact Retinal Tissue and Retinal Pigment Epithelium Identified within a Coloboma Via High-Speed, Ultrahigh Resolution Optical Coherence Tomography," Retin. Cases Brief Rep. 5(1), 46-48, Winter 2011. 14. S. Sakadžić, E. Roussakis, M.A. Yaseen, E.T. Mandeville, V.J. Srinivasan, K. Arai, S. Ruvinskaya, A. Devor,  E.H. Lo, S.A. Vinogradov, D.A. Boas, “Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue, ” Nat. Methods 7, 755-U125, September 2010. 15. V.J. Srinivasan, S. Sakadžić, I. Gorczynska, S. Ruvinskaya, W. Wu, J.G. Fujimoto, D.A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Exp. 18(3), 2477-2494, January 2010. 16. V.J. Srinivasan, J.Y. Jiang, M.A. Yaseen, H. Radhakrishnan, W. Wu, S. Barry, A.E. Cable, D.A. Boas, “Rapid volumetric angiography of cortical microvasculature with optical coherence tomography,” Opt. Lett. 35, 43-45, January 2010. 17. M.A. Yaseen, V.J. Srinivasan, S. Sakadžić, W. Wu, S. Ruvinskaya, S.A. Vinogradov, and D.A. Boas, "Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy," Opt. Exp. 17, 22341-22350, December 2009. 18. V.J. Srinivasan, S. Sakadžić, I. Gorczynska, S. Ruvinskaya, W. Wu, J.G. Fujimoto, and D. Boas, “Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography,” Opt. Lett. 34, 3086-3088, October 2009. 19. A.C. Sull, L.N. Vuong, L.L. Price, V.J. Srinivasan, I. Gorczynska, J.G. Fujimoto, J.S. Schuman, and J.S. Duker, “Comparison of spectral Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retin.-J. Retin. Vitr. Dis. (30), 235-245, February 2010. 20. A.J. Witkin, L.N. Vuong, V.J. Srinivasan, I. Gorczynska, E. Reichel, C.R. Baumal, A.H. Rogers, J.S. Schuman, J.G. Fujimoto, and J.S. Duker, “High-speed ultrahigh resolution optical coherence tomography before and after ranibizumab for age-related macular degeneration,” Ophthalmology 116, 956-963, May 2009. 21. I. Gorczynska, V.J. Srinivasan, L.N. Vuong, R.W.S. Chen, J.J. Liu, E. Reichel, M. Wojtkowski, J.S. Schuman, J.S. Duker, and J.G. Fujimoto, “Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration,” Br. J. Ophthalmol. 93, 603-609, May 2009. 22. V.J. Srinivasan, Y. Chen, J.S. Duker, and J.G. Fujimoto, “In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT,” Opt. Exp. 17, 3861-3877, March 2009. 23. Y. Chen, L.N. Vuong, J. Liu, J. Ho, V.J. Srinivasan, I. Gorczynska, A.J. Witkin, J.S. Duker, J. Schuman, and J.G. Fujimoto, “Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration,” Opt. Exp. 17, 4046-4060, March 2009 24. V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto,  “Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head,” Invest. Ophthalmol. and Vis. Sci. 49, 5103-5110, November 2008. 25. B.R. Biedermann, W. Wieser, C.M. Eigenwillig, G. Palte, D.C. Adler, V. Srinivasan, J.G. Fujimoto, and R. Huber, “Real time en face Fourier-domain optical coherence tomography with direct hardware frequency demodulation,” Opt. Lett. 33, 2556-2558, November 2008. 26. B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, “Ultrahigh speed spectral/Fourier domain optical coherence tomography ophthalmic imaging at 70,000-312,500 axial scans per second,” Opt. Exp. 16, 15149-15169, September 2008. 27. T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M.L. Gabrielle, V. Srinivasan, J.G. Fujimoto, J.S. Duker, and J.S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 115, 782-789, May 2008. 28. M.L. Gabriele, H. Ishikawa, G. Wollstein, R.A. Bilonick, K.A. Townsend, L. Kagemann, M. Wojtkowski, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, and J.S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. and Vis. Sci. 49, 2315-2321, June 2008. 29. V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, “Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. and Vis. Sci. 49, 1571-1579, April 2008. 30. R.W. Chen, I. Gorczynska, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, and E. Reichel, “High-speed ultrahigh-resolution optical coherence tomography findings in chronic solar retinopathy,” Retin. Cases Brief Rep. 2, 103-105, Spring 2008. 31. A.J. Witkin, M. Wojtkowski, E. Reichel, V.J. Srinivasan, J.G. Fujimoto, J.S. Schuman, and J.S. Duker, “Photoreceptor disruption secondary to posterior vitreous detachment as visualized using high-speed ultrahigh-resolution optical coherence tomography,” Arch. Ophthalmol 125, 1579-1580, November 2007. 32. M.K. Yoon, R.W. Chen, T.R. Hedges, III, V.J. Srinivasan, I. Gorczynska, J.G. Fujimoto, M. Wojtkowski, J.S. Schuman, and J.S. Duker, “High-speed, ultrahigh resolution optical coherence tomography of the retina in Hunter syndrome,” Ophthalmic Surg. Lasers Imaging 38, 423-428, September/October 2007. 33. V. Christopoulos, L. Kagemann, G. Wollstein, H. Ishikawa, M.L. Gabriele, M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, J.S. Duker, D.K. Dhaliwal, and J.S. Schuman, “In vivo corneal high-speed, ultra-high-resolution optical coherence tomography,” Arch. Ophthalmol. 125, 1027-1035, August 2007. 34. R. Huber, D.C. Adler, V.J. Srinivasan, I. Gorczynska, and J.G. Fujimoto, “Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second,” Opt. Lett.  32, 2049-2051, July 2007. 35. M.L. Gabriele, H. Ishikawa, G. Wollstein, R.A. Bilonick, L. Kagemann, M. Wojtkowski, V.J. Srinivasan, J.G. Fujimoto, J.S. Duker, and J.S. Schuman, “Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning,” Invest. Ophthalmol. Vis. Sci. 48, 3154-3160, July 2007. 36. L. Kagemann, G. Wollstein, M. Wojtkowski, H. Ishikawa, K.A. Townsend, M.L. Gabriele, V.J. Srinivasan, J.G. Fujimoto, and J.S. Schuman, “Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography,” J. Biomed. Opt. 12, 04212-1—8, July/August 2007. 37. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmoska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, “Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies,” J. Biomed. Opt. 12, 041207-1 – 11, July/August 2007. 38. J.A. Rodriguez-Padilla, T.R. Hedges, III, B. Monson, V. Srinivasan, M. Wojtkowski, E. Reichel, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, “High-speed, ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy,” Arch. Ophthalmol. 125, 775-780, June 2007. 39. M.Y. Kahook, R.J. Noecker, H. Ishikawa, G. Wollstein, L. Kagemann, M. Wojtkowski, J.S. Duker, V.J. Srinivasan, J.G. Fujimoto, and J.S. Schuman, “Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure,” Am. J. Ophthalmol. 143, 697-699, April 2007. 40. V.J. Srinivasan, R. Huber, I. Gorczynska, J.G. Fujimoto, J.Y. Jiang, P. Riesen, and A.E. Cable, “High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850nm,” Opt. Lett. 32, 361-363, February 2007. 41. B.-B. Gao, A. Clermont, S. Rook, S.J. Fonda, V.J. Srinivasan, M. Wojtkowski, J.G. Fujimoto, R.L. Avery, P.G. Arrigg, S.-E. Bursell, L.P. Aiello, and E.P Feener, “Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrean activation,” Nature Med., 13, 181-188, February 2007. 42. B.K. Monson, P.B. Greenberg, E. Greenberg, J.G. Fujimoto, V.J. Srinivasan, and J.S. Duker, “High-speed, ultra-high-resolution optical coherence tomography of acute macular neuroretinopathy,” Br. J. Ophthalmol. 91, 119-120, January 2007. 43. V.J. Srinivasan, T.H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S.-E. Bursell, Q.H. Song, J. Lem, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh resolution OCT,” Invest. Ophthalmol. and Vis. Sci. 47, 5522-5528, December 2006. 44. L. Kagemann, G. Wollstein, H. Ishikawa, M.L. Gabrielle, V.J. Srinivasan, M. Wojtkowski, J.S. Duker, J.G. Fujimoto, and J.S. Schuman, “Persistence of Cloquet’s canal in normal healthy eyes,” Am. J. Ophthalmol. 142, 862-864, November 2006. 45. V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, J.S. Duker, and J.G. Fujimoto, “High-definition and three-dimensional imaging of macular pathologies with high-speed, ultrahigh resolution optical coherence tomography,” Ophthalmology, 113, 2064.e1-2054.e14, November 2006. 46. V.J. Srinivasan, M. Wojtkowski, J.G. Fujimoto, and J.S. Duker, “In vivo measurement of retinal physiology with high-speed ultrahigh resolution optical coherence tomography,” Opt. Lett., 31, 2308-2310, August 2006. 47. M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, “Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography,” Ophthalmology 112, 1734-1746, October 2005. 48. M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, J.S. Duker, and A. Kowalevicz, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Exp. 12, 2402-2422, May 2004.
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