Departmental Invited Seminar Series: Changqing Li, Assistant Professor of Bioengineering, UC Merced

“Hybrid Optical Tomography for Small Animal Imaging”

Optical imaging in small animals has been used widely because of its unique features including non-ionization, cost effectiveness, high intrinsic contrast and well-developed exogenous molecular probes. Its applications in imaging targets (e.g. cancers or stem cells) deeper than 1 mm below skin are limited by optical scattering which degrades spatial resolution and quantification of the optical imaging.

To overcome this obstacle, two hybrid imaging methods have been proposed, x-ray luminescence optical tomography (XLOT) and simultaneous positron emission tomography and fluorescence optical tomography (PET/FOT). In the XLOT, collimated x-ray beams excite nanoparticles to emit optical photons which are measured to reconstruct the nanoparticle distribution inside tissues. XLOT has the high sensitivity of optical imaging and high resolution of x-rays. The PET/FOT is implemented by a conical mirror insertion into the PET scanner. The performances of the PET/FOT were evaluated and validated with in vivo imaging experiments.

When: Thursday, November 8, 2012 4:10 PM

Where: 1005 GBSF