Advancing Human Health

Biomedical Engineer Leads Dream Team Developing In Utero Therapy for Rare Neurological Disorder

Aijun Wang, a professor of biomedical engineering and surgery at UC Davis, is leading an interdisciplinary team of researchers to develop in-utero gene editing technology to fix mutations related to the UBE3A Gene.

Overexpression of this gene contributes to Dup15q syndrome, which affects 1 in 5,000 individuals, and its absence leads to Angelman syndrome. Both syndromes are profound neurodevelopmental conditions that could co-occur with autism, epilepsy and severe intellectual disability.

A Chip to Measure Immunity

Every winter, influenza returns with a new variant. People who have previously been infected with or vaccinated against flu may have some protection, but this depends on how well their immune system’s “memory” of the previous virus or vaccine cross-reacts with the new variant. At present, there is no good way to measure this.