Biomedical Engineering Professor Cheemeng Tan Receives NIH Grant to Engineer Synthetic Bacteria For Translational Clinical Medicine

Unlike the dinosaurs in Jurassic Park, the synthetic bacteria in Cheemeng Tan’s lab will not find a way to replicate. As he explains, ‘We will modify our synthetic bacteria using a method that turns them into controllable living micromachines.’ That means clinicians will be able to administer them in a controlled way for medical applications, including delivering medicine within the body, CRISPR-Cas gene editing, killing cancer cells, and administering probiotics and oral vaccines.

How Cadherins Let Cells Hold On and Let Go of Each Other

A fundamental question in cell biology is, how do cells control how strongly to stick to each other? Sometimes, cells need to be quite tightly glued together, for example in the lining of a blood vessel. At other times, they need to be able to peel apart. Understanding how cells can stick or unstick from each other is important for understanding tissue growth and wound healing. Cancers metastasize when tumor cells can come unstuck from a tumor and spread to other tissues.

Marcu Lab Receives R01 Grant to Continue FLIm Robotic Cancer Surgery Research

Laura Marcu, professor of biomedical engineering, has received a $3.2M grant from the National Institutes of Health (NIH) to continue her groundbreaking research on clinical applications of Fluorescent Lifetime Imaging (FLIm). Working with  surgeons in the UC Davis Department of Otolaryngology and in collaboration with Intuitive Surgical Inc. her team will add an innovative FLIm technology to the da Vinci robotic surgical system to better identify cancerous tissue during  trans-oral-robotic-surgery (TORS).

Measuring Brain Blood Flow and Activity With Light

Originally posted by Andy Fell

A new, noninvasive method for measuring brain blood flow with light has been developed by biomedical engineers and neurologists at the University of California, Davis, and used to detect brain activation. The new method, functional interferometric diffusing wave spectroscopy, or fiDWS, promises to be cheaper than existing technology and could be used for assessing brain injuries, or in neuroscience research. The work is published May 12 in Science Advances.

Ariño-Estrada Receives R01 Award for Gamma Detection System

Dr. Gerard Ariño-Estrada, an assistant project scientist in the Cherry Lab, has received an R01 award from the National Institutes of Health (NIH) to develop a gamma detection system that will improve the quality control of radiotherapy using protons and improve its efficacy.

New Imaging Diagnostic Tool Lights Up Tumors During Brain Cancer Surgery

(SACRAMENTO) — A new optical imaging technology developed at the University of California, Davis, could help neurosurgeons visually and objectively differentiate between healthy and cancerous tissues during brain cancer surgeries. The technology, called Fluorescence Lifetime Imaging (FLIm), could allow surgeons to more precisely and thoroughly remove malignant tumors.

UC Davis Engineers Make Advances in Cell Adhesion

Sanjeevi Sivasankar and Soichiro Yamada, both associate professors in the department of biomedical engineering, took on the challenge of developing a technology capable of discovering membrane protein binding partners on the cell surface.

UC Davis Researchers Collaborating with Yale on $10.2M BRAIN Initiative Grant

Scientists from Yale and UC Davis will work with United Imaging to build the next-generation human brain PET scanner, the NeuroeXplorer (NX), to be installed at the Yale Positron Emission Tomography (PET) Center in two years. Funded by a five-year, $10.2 million BRAIN Initiative grant from the National Institutes of Health, the NX will replace the Yale PET Center’s HRRT system, which is currently the highest resolution brain scanner in the world.