Biomedical Engineering

John M. Boone


Professor and Vice Chair (Research) of Radiology
Professor of Biomedical Engineering

(916) 734-3158
Imaging Center / UCDMC
Boone Lab


American Association of Physicists in Medicine (AAPM) Fellow
Chair, Science CouncilAmerican College of Radiology (ACR) Fellow
Society of Breast Imaging (SBI) Fellow
Radiological Society of North America (RSNA)
Associate Editor,Radiology
Chair, Committee on Radiation Dose and Image Quality in Computed Tomography, International Commission for Radiological Units and Measurement (ICRU).

Major Research Interest

Breast Imaging and Computed Tomography Research.

Research Interest

Mammography is the current standard for breast cancer screening, however it is acknowledged by experts in imaging that mammography is not ideal.  We are studying the potential of tomographic imaging of the breast using a custom-designed breast CT scanner.  The breast CT system is capable of generating 300 to 500 tomographic slices of the breast using the same radiation levels as two view mammography, and these images allow the radiologist to view regions in the breast unobstructed by overlaying normal anatomical tissue, which can obscure lesion identification and reduce cancer detection performance, especially in the dense breast.   We have designed, fabricated, and tested two prototype breast CT scanners in the lab, and were the first group in the world to perform cone beam breast CT on live women.  We have performed over 140 breast CT studies as of January 2008.  Future advances on the breast CT system include the addition of positron emission tomography (PET), robotic biopsy, and the addition of therapeutic capabilities including radiofrequency ablation and radiation therapy.

Research Papers

Bushberg JT, Seibert JA, Leidholdt EM, Boone JM. The Essential Physics of Medical Imaging, Second Edition,  Lippincott, Williams and Wilkins, Baltimore, MD 2002, ISBN: 0-683-30118-7

ALC Kwan, JM Boone, N Shah, “Evaluation of x-ray scatter properties in a dedicated cone-beam breast CT scanner”, Med Phys 2005; 32: 2967-2975

Seibert JA, Boone JM. X-ray imaging physics for nuclear medicine technologists. Part 2: X-ray interactions and image formation. J Nucl Med Technol 2005; 33:3-18

Boone JM, Kwan ALC, Seibert JA, Shah N, Lindfors KK. Technique factors and their relationship to radiation dose in pendant geometry breast CT. Med Phys 2005; 32: 3767-3776

Boone JM. Science to Practice: What parameters are most accurate in predicting appropriate technique factors for computed tomography scans? Radiology 2005; 236: 377-378

Lamare F, Bowen SL, Visvikis D, Cortes P, Wu Y, Tran V-H, Boone JM, Cherry SR, Badawi RD. Design simulation of a rotating dual-headed PET scanner for breast imaging. Nuclear Science Symposium Conference Record 2005; 3: 1524–1529

Kwan ALC, Seibert JA, Boone JM. An improved method for flat-field correction of flat panel x-ray detectors. Med Phys 2006; 33: 391-393

Yang K, Kwan ALC, Miller DF, Boone JM. A general geometric calibration method for cone beam CT systems. Med Phys 2006; 33: 1695-1706

Boone JM, Lindfors KK. Breast CT: potential for breast cancer screening and diagnosis. Future Oncol 2006; 2: 351-356

Boone JM, Kwan AL, Yang K, Burkett GW, Lindfors KK, Nelson TR Computed tomography for imaging the breast. J Mamary Gland Biol Neoplasia 2006; 11: 103-111

Yang K, Kwan ALC, JM Boone JM. Computer modeling of the spatial resolution properties of a dedicated breast CT scanner. Med Phys 2006; 34(6): 2059-2069

Boone JM. Extreme multi-slice CT: Opportunities, challenges, and concerns. Radiology 241: 334-7 (2006)

Schwoebel PR, Boone JM. Stationary x-ray source for tomographic medical imaging. SPIE 2006; 6142: 61423N1-3

Wu Y, Yang K, Packard N, Fu L, Stickel J, Tran V-H, Qi J, Boone JM, Cherry SR, Badawi RD. Characteristics of the PET component of a dedicated breast PET/CT scanner prototype. Nuclear Science Symposium Conference Record 2006; 4: 2335–2339

Bowen SL, Yang K, Wu Y, Cherry SR, Boone JM, Moses WW, Badawi RD. Monte Carlo simulation study of several camera designs for the PET component of a dedicated breast PET/CT scanner. Nuclear Science Symposium Conference Record 2006; 6: 3920–3924

Smathers RL, Boone JM, Lee LJ, Berns EA, Miller RA, Write AM. Radiation dose reduction for augmentation mammography AJR 2007; 188(5): 1414-21

Kellner AL, Nelson TR, Cervino LI, Boone JM. Simulation of the mechanical compression of breast tissue. IEEE Trans Biomedical Engineering 2007; 54(10): 1885-1891

Kwan ALC, Boone JM, Yang K, Huang S-Y. Evaluation of the spatial resolution characteristics of a cone-beam breast CT scanner. Medical Physics 2007; 34(1): 275-281

Boone JM. The trouble with CTDI100 Med Phys, 2007; 34(4): 1364-1371

Boone JM, Radiological Interpretation 2020: towards quantitative image assessment, Med Phys 34:4173-9 (2007)

Liang H, Yang Y, Wu Y, Boone JM, Cherry SR, A microPET/CT system for in vivo small animal imaging, Phys Med Biol 52:3881-94 (2007)

Yang K, Kwan AL, Boone JM, Computer modeling of the spatial resolution properties of a dedicated breast CT system, Med Phys 34:2059-69 (2007)